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Immunotherapy Special Collection
2 Results
- Letter to the EditorOpen Access
Introduction to the special edition on immunotherapy and radiation oncology
Advances in Radiation OncologyVol. 3Issue 4p484–485Published in issue: October, 2018- Sophia Bornstein
- Silvia C. Formenti
Cited in Scopus: 0This special edition of Advances in Radiation Oncology is focused on the role of radiation therapy in the context of immunotherapy. Radiation therapy has been used for more than 50 years as an effective modality to eradicate gross and microscopic cancer. Over the past few decades, a distinct role for radiation from that of directly killing tumor cells has emerged. Tumor responses outside of the radiated field, or abscopal effects (ab scopus = outside the target), have been described, although they are rare with radiation alone. - Critical ReviewOpen Access
Generating antitumor immunity by targeted radiation therapy: Role of dose and fractionation
Advances in Radiation OncologyVol. 3Issue 4p486–493Published in issue: October, 2018- Eric C. Ko
- Kimberly Thomas Benjamin
- Silvia C. Formenti
Cited in Scopus: 43Accumulating evidence supports the role of radiation therapy in the induction of antitumor immunity. With recent advancements in stereotactic radiation therapy, there is increasing appreciation that, when combined with immune checkpoint blockade, the type of radiation dose and fractionation regimen selected may both influence local tumor control and also affect the generation of immune responses that are important for systemic control. Although a broad range of radiation dose and fractionation schema have been tested in both the preclinical and clinical settings, recent preclinical evidence suggests the existence of a dose per fraction threshold beyond which radiation becomes less effective in generating tumor immune responses.
