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Immunotherapy Special Collection
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- Critical ReviewOpen Access
Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors
Advances in Radiation OncologyVol. 3Issue 4p512–519Published in issue: October, 2018- Susannah G. Ellsworth
Cited in Scopus: 86Radiation-induced lymphopenia (RIL) is the result of direct toxicity to circulating lymphocytes as they traverse the irradiated field, occurs in 40% to 70% of patients who undergo conventional external beam radiation therapy, and is associated with worse outcomes in multiple solid tumors. As immunotherapy strategies evolve, a better understanding of radiation's effects on the immune system is needed in order to develop rational methods of combining RT with immunotherapy.
