x
Filter:
Filters applied
- Immunotherapy Special Collection
- Benjamin, Kimberly ThomasRemove Benjamin, Kimberly Thomas filter
Publication Date
Please choose a date range between 2018 and 2018.
Immunotherapy Special Collection
1 Results
- Critical ReviewOpen Access
Generating antitumor immunity by targeted radiation therapy: Role of dose and fractionation
Advances in Radiation OncologyVol. 3Issue 4p486–493Published in issue: October, 2018- Eric C. Ko
- Kimberly Thomas Benjamin
- Silvia C. Formenti
Cited in Scopus: 43Accumulating evidence supports the role of radiation therapy in the induction of antitumor immunity. With recent advancements in stereotactic radiation therapy, there is increasing appreciation that, when combined with immune checkpoint blockade, the type of radiation dose and fractionation regimen selected may both influence local tumor control and also affect the generation of immune responses that are important for systemic control. Although a broad range of radiation dose and fractionation schema have been tested in both the preclinical and clinical settings, recent preclinical evidence suggests the existence of a dose per fraction threshold beyond which radiation becomes less effective in generating tumor immune responses.
