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Critical Review| Volume 8, ISSUE 2, 101042, March 2023

Magnetic Resonance Imaging–Based Delineation of Organs at Risk in the Head and Neck Region

Open AccessPublished:July 30, 2022DOI:https://doi.org/10.1016/j.adro.2022.101042

      Abstract

      Purpose

      The aim of this article is to establish a comprehensive contouring guideline for treatment planning using only magnetic resonance images through an up-to-date set of organs at risk (OARs), recommended organ boundaries, and relevant suggestions for the magnetic resonance imaging (MRI)–based delineation of OARs in the head and neck (H&N) region.

      Methods and Materials

      After a detailed review of the literature, MRI data were collected from the H&N region of healthy volunteers. OARs were delineated in the axial, coronal, and sagittal planes on T2-weighted sequences. Every contour defined was revised by 4 radiation oncologists and subsequently by 2 independent senior experts (H&N radiation oncologist and radiologist). After revision, the final structures were presented to the consortium partners.

      Results

      A definitive consensus was reached after multi-institutional review. On that basis, we provided a detailed anatomic and functional description and specific MRI characteristics of the OARs.

      Conclusions

      In the era of precision radiation therapy, the need for well-built, straightforward contouring guidelines is on the rise. Precise, uniform, delineation-based, automated OAR segmentation on MRI may lead to increased accuracy in terms of organ boundaries and analysis of dose-dependent sequelae for an adequate definition of normal tissue complication probability.

      Introduction

      Accurate organ-at-risk (OAR) delineation in the era of precision radiation therapy (RT) is essential for the irradiation of head and neck (H&N) cancer. Both postoperative and definitive organ-preserving RT with or without chemotherapy are widely applied in the complex management of this disease. Although RT is highly effective in the treatment of cancer, a substantial rate of serious acute side effects and often severe, treatment-related late toxicities occur. Acute mucositis during dose delivery, as well as late functional damages of healthy organs, may lead to xerostomia and swallowing difficulties, significantly deteriorating the quality of life of patients. A consistent definition and delineation of OARs using highly selective, conformal plans is vital to spare normal structures.
      Both traditionally and at the present time, the generally used imaging method for contouring purposes is computed tomography (CT). A consensus guideline
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      was published in 2015 on CT-based OAR delineation for the H&N region. However, the hegemony of CT is challenged by newly emerged, advanced methods that provide detailed images with far superior soft-tissue resolution compared with CT (magnetic resonance imaging [MRI]).
      • Widmann G
      • Henninger B
      • Kremser C
      • Jaschke W.
      MRI sequences in head & neck radiology–State of the art.
      ,
      • Dai YL
      • King AD.
      State of the art MRI in head and neck cancer.
      MRI-only treatment planning has several clinical advantages, such as the avoidance of multiple imaging processes and exposure to ionizing radiation during imaging. The latter has a greater relevance if repeated imaging is applied for replanning purposes during adaptive RT.
      However, MRI-only based contouring has a number of drawbacks as well. Due to the more complex physical background, selecting and interpreting adequate sequences require more experience. Moreover, getting to know the specific MRI characteristics of the given OARs may take a longer time and more practice. In the future, owing to automated OAR delineation, this learning process will become needless, and errors due to human mistakes will be less likely to occur. With the availability of such modalities, the need for a large number of accurate OAR contours in the H&N region, including subunits of larger organs and organelles, can be satisfied. Although MRI has long been used for tumor delineation, its implication in OAR contouring remains a question of debate.
      • Lukovic J
      • Henke L
      • Gani C
      • et al.
      MRI-based upper abdominal organs-at-risk atlas for radiation oncology.
      • Olsson Nyholm T
      • Wieslander E
      • et al.
      Initial experience with introducing national guidelines for CT- and MRI-based delineation of organs at risk in radiotherapy.
      • Yuan J
      • Wong O
      • Law MWK
      • Ding Y
      • Cheung KY
      • Yu SK.
      Delineation variability of head and neck organs at risk on T1-weighted isotropic magnetic resonance images: A pilot study on healthy volunteers.
      Since 2015, many studies have been published, focusing on new potential OARs in the anatomic region at hand. As a result of this process, numerous different sets of OARs coexist, in some cases accompanied by MRI-based contouring atlases. The purpose of this paper is to establish a comprehensive contouring guideline for treatment planning using only magnetic resonance images through an up-to-date set of OARs, recommended organ boundaries, and relevant suggestions of the MRI-based delineation of OARs.

      Methods and Materials

      The ongoing project, “Deep-Learning MR-only Radiation Therapy”, aims to develop a software that can provide automatic OAR contours on magnetic resonance images.
      • Rusko L
      • Kolozsvari B
      • Takacs P
      • et al.
      Automated organ delineation in T2 head MRI using combined 2D and 3D convolutional neural networks.
      The first phase of the development required numerous precise, manually contoured expert cases. During the project, the need emerged for a definition of MRI acquisition techniques and delineation of OARs in the H&N region on magnetic resonance images. To that aim, the technical details of MRI acquisition for treatment planning, reasonably required MRI sequences, and an up-to-date set of OARs were defined, relying on the latest existing guidelines.
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      ,
      • Hoebers F
      • Yu E
      • Eisbruch A
      • et al.
      A pragmatic contouring guideline for salivary gland structures in head and neck radiation oncology: The MOIST target.
      • Gawryszuk A
      • Bijl HP
      • Holwerda M
      • et al.
      Functional swallowing units (FSUs) as organs-at-risk for radiotherapy. PART 2: Advanced delineation guidelines for FSUs.
      • Eekers DBP
      • in ’t Ven L
      • Roelofs E
      • et al.
      The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology.
      • Beddok A
      • Faivre JC
      • Coutte A
      • et al.
      Practical contouring guidelines with an MR-based atlas of brainstem structures involved in radiation-induced nausea and vomiting.
      • Wu AJ
      • Bosch WR
      • Chang DT
      • et al.
      Expert consensus contouring guidelines for IMRT in esophageal and gastroesophageal junction cancer.
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      • Truong MT
      • Nadgir RN
      • Hirsch AE
      • et al.
      Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.
      The method comprised of a systematic review of the latest publications and discussions for a consensus in divergent points by representatives of the participating institutions.
      The next step was MRI data collection from the H&N region of 7 healthy volunteers in a diagnostic setting (supine position, dedicated H&N coil; Table 1). The OARs were delineated using the ECLIPSE treatment planning system (Varian Medical Systems, version 13.6) in the axial, coronal, and sagittal planes on T2-weighted sequences. Every contour defined was revised by 4 radiation oncologists and subsequently by 2 independent senior experts (H&N radiation oncologist and radiologist). After this 2-step revision, the final structures were presented to the consortium partners in Rotterdam, The Netherlands. A definitive consensus was reached after multi-institutional review. To visualize our findings and suggestions, we compiled an atlas containing an expert case (Appendix E1). MRI for OAR delineation was based on 2- and 3-dimensional, T2-weighted, fast-spin echo (FSE) sequences with sufficient geometric coverage to include all relevant OARs (ie, top of head to middle of neck). More specifically, the T2 FSE sequences included 2-dimensional fast-recovery FSE, 2-dimensional PROPELLER (GE Healthcare, Waukesha, WI), and 3-dimensional CUBE (GE Healthcare, Waukesha, WI). Detailed sequence parameters are outlined in Table 1.
      Table 1Scan parameters for 3 T2-weighted sequences used for organ-at-risk delineation
      2-Dimensional T2 fast-recover, fast-spin echo2-Dimensional T2 PROPELLER3-Dimensional T2 CUBE
      Magnetic resonance scanner modelGE DISCOVERY MR750wGE SIGNA ArtistGE SIGNA Artist
      Radiofrequency receive coil arrayAIR RT Head&NeckGEM Head&NeckGEM Head&Neck
      Main magnetic field strength, T31.51.5
      Bandwidth, kHz
      Pixel bandwidth × rows.
      62.583.3125
      Repetition time, ms1186676242002
      Echo time, ms99.387.376.6
      Echo train length2226100
      Scan time, s332.6229.1259.0
      Scan orientationAxialaxialsagittal
      Field of view, mm2300 × 300300 × 300340 × 340
      Acquired resolution, mm2
      Reconstruction diameter/acquisition matrix.
      1.04 × 1.041.04 × 1.041.18 × 1.18
      Interpolated resolution, mm2
      Reconstruction diameter/rows.
      0.59 × 0.590.59 × 0.590.66 × 0.66
      Slice thickness, mm331
      Number of slices, n10080340
      low asterisk Pixel bandwidth × rows.
      Reconstruction diameter/acquisition matrix.
      Reconstruction diameter/rows.
      From the point of view of tissue contrast, no significant differences were found between the tested sequences. However, 2-dimensional sequences are more sensitive to patient motion (swallowing, eye movements); thus, imaging artifacts are more likely to occur. This is the main reason why the volunteer scan included in the atlas is a 3-dimensional Sagittal T2 CUBE sequence, although our contouring atlas is applicable to any diagnostic T2-weighted MRI sequence. The reconstruction diameter was 350 mm, the pixel size 0.664 mm, and the spacing between slices 0.5 mm. The selection criteria for the atlas case included high resolution, good contrast, and lack of imaging artifacts. Before manual contouring, the original scan was reformatted to axial orientation and isotropic voxel size (0.664 mm) using the Volume Viewer application of Advantage Workstation, version 4.7, to make the scan compatible with all RT planning software.
      Our choice of MRI sequence relied on a scoring table (Table 2) in which the visibility of the OARs was evaluated on T1- and T2-weighted MRI sequences, as well as on CT. The most important aspects of evaluation were sharpness of margins and demarcation from the surrounding tissues. A scale ranging from 1 to 3 was used, where 3 stood for excellent, 2 for average, and 1 for poor visibility. Based on the results of this evaluation, we found that T2-weighted MRI sequences are more suitable for OAR delineation than T1 sequences. In addition to organ contouring, MRI-only RT planning requires synthetic CT to enable dose calculation. The technical feasibility of MRI-based synthetic CT was demonstrated previously by several studies.
      • Wiesinger F
      • Bylund M
      • Yang J
      • et al.
      Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning.
      ,
      • Blanc-Durand P
      • Khalife M
      • Sgard B
      • et al.
      Attenuation correction using 3D deep convolutional neural network for brain 18F-FDG PET/MR: Comparison with Atlas, ZTE and CT based attenuation correction.

      Results

      Herein, we summarize our findings during the contouring session, as well as the recommended OAR boundaries. Table 2 also contains useful information on the MRI characteristics of the different OARs by the end of this section.

      Parotid glands

      The parotid gland is the largest of the major salivary glands, approximately 55 to 60 mm in craniocaudal and 30 to 35 mm in anteroposterior dimension.
      • Hoebers F
      • Yu E
      • Eisbruch A
      • et al.
      A pragmatic contouring guideline for salivary gland structures in head and neck radiation oncology: The MOIST target.
      The parotid gland is composed of an inverted, triangle-shaped, superficial and deep lobe, located behind the ramus of the mandible. A number of important vessels and nerves pass through the gland. The facial nerve pierces its substance in the posteroanterior direction, which can be regarded as the border between the superficial and deep lobes. Deep to the facial nerve passes the external carotid artery to terminate as 2 branches inside the parotid gland (maxillary and superficial temporal arteries). Superficial to the arteries are the superficial temporal and maxillary veins, joining to form the retromandibular vein.

      Contouring suggestions

      The delineation of the external carotid artery and retromandibular vein was carried out in a few cases to precisely define the medial border of the organ and distinguish between vessels and the styloid process, as well as the muscles arising from the latter. An accessory parotid gland is sometimes present alongside the parotid duct, on the outer surface of the masseteric muscle that has to be included in the contour. Fatty infiltration/replacement of the secretory tissue may be present in patients of older age, which may make the outline of the organ more difficult to define.
      • Sousa Garcia D
      • Bussoloti Filho I
      Fat deposition of parotid glands.
      This may also arise as a therapeutic side effect of previous irradiation. Table 3 shows the recommended anatomic boundaries.
      Table 3Anatomic borders of salivary glands
      Organ boundariesParotid glandsSubmandibular glands
      AnteriorMasseteric muscle, mandibular ramus, pterygoid musclesPosterior margin of mylohyoid muscle, with the deep process spreading above the mylohyoid muscle
      PosteriorSternocleidomastoid muscle and the posterior belly of the digastric muscleParapharyngeal space, great vessels of the neck
      MedialStyloid process, styloglossus, stylohyoid, and stylopharyngeal musclesSuperior: lateral surface of hyoglossus and partly mylohyoid muscles

      Middle: lateral surface of styloglossus and stylohyoid muscles, digastric muscle

      Inferior: lateral surface of the body of hyoid bone, pharyngeal constrictor muscles
      LateralPlatysma, subcutaneous tissueSuperior: medial surface of medial pterygoid muscle

      Middle: medial surface of the body of the mandibular bone

      Inferior: platysma, investing layer of deep cervical fascia, fat tissue
      CranialSuperior wall of the external auditory canal, mastoid processMedial pterygoid muscle
      CaudalNo distinct border, the organ gradually disappears in the fat tissue of the neckNo distinct border, the organ gradually disappears in the fat tissue of the neck

      Submandibular glands

      The largest portion of the walnut-sized (approximately 27 mm in length; 13-14 mm in width) submandibular gland lies in the submandibular triangle, and usually exceeds the level of the inferior border of the mandibular corpus (ie, cranial border of submandibular triangle) in the cranial direction. Inferiorly, this portion of the gland reaches the insertion of the stylohyoid muscle (body and greater horn of hyoid bone) and the intermediate tendon of the digastricus. A tongue-like extension of the gland, often referred to as the deep process, arises from the medial surface of the gland, and spreads above the mylohyoid muscle. The facial artery leads a tortuous path, which passes through the medial part of the organ, and the facial vein is situated on the superficial surface.

      Contouring suggestions

      Table 3 shows the recommended anatomic boundaries.

      Mandible

      The mandible, or jawbone, consists of a parabolic-shaped body that is connected by a right and left ramus to the rest of the cranium. The 2 rami terminate in the condyles, which form the articular head of the temporomandibular joints.

      Contouring suggestions

      The alveoli or teeth sockets of the mandibular corpus are still included in the contour, but not the teeth. We omitted the coronoid process from the contour, because its cranial border is hard to define univocally on axial MRI slices, and radiation necrosis affects primarily the body.
      • Rathy R
      • Sunil S
      • Nivia M.
      Osteoradionecrosis of mandible: Case report with review of literature.

      Supraglottic larynx

      The upper part of the larynx is composed of the epiglottis, aryepiglottic folds, false vocal or vestibular cords, arytenoid cartilages, and mucosa coating them. Brouwer et al
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      defined the inferior border of the supraglottis as the cranial edge of arytenoid cartilages. However, this contradicts the fact that the vestibular cords form an integral part of the supraglottic larynx, because their origin and insertion (anterolateral surface of arytenoid cartilage, just above vocal process; angle of thyroid cartilage below attachment of epiglottis) is situated below the apex of the arytenoids. The pyriform sinus belongs to the hypopharynx and is excluded from the contour.

      Glottic larynx/glottic area

      The glottic larynx is an anatomic subsite of the larynx, below the supraglottis and above the subglottis. The name of the area is derived from the glottis, the gap between the true vocal cords. According to the seventh edition of the American Joint Committee on Cancer staging manual,
      • Edge SB
      • Byrd DR
      • Compton CC
      • Fritz AG
      • Greene FL
      AJCC Cancer Staging Manual Seventh Edition.
      • Castelijns JA
      • Doornbos J
      • Verbeeten Jr, B
      • Vielvoye GJ
      • Bloem JL.
      MR imaging of the normal larynx.
      the glottis contains the true vocal cords, including its anterior and posterior commissures. The overall thickness of the structure is approximately 10 mm in the horizontal plane.

      Contouring suggestions

      Table 4 shows the recommended anatomic boundaries of the laryngeal structures.
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      • Edge SB
      • Byrd DR
      • Compton CC
      • Fritz AG
      • Greene FL
      AJCC Cancer Staging Manual Seventh Edition.
      • Ferlito A
      • Rinaldo A.
      The pathology and management of subglottic cancer.
      • Ferlito A
      • Rinaldo A.
      The pathology and management of subglottic cancer.
      Table 4Anatomic borders of laryngeal structures and oral cavity
      Organ boundariesSupraglottic larynxGlottic larynxOral cavity
      AnteriorHyoid bone, pre-epiglottic space, thyroid cartilage
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      Thyroid angleInner surface of superior and inferior dental arches
      PosteriorPosterior pharyngeal wallInner surface of cricoid and arytenoid cartilagesPosterior border of soft palate and uvula, root of the tongue
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      MedialNA (lumen of larynx)NA
      LateralInner surface of thyroid cartilageInner surface of dental arches, maxilla, and mandible
      CranialTip of epiglottis
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      Caudal boundary of supraglottic larynx (ie, arytenoids)Mucosa of hard and soft palates
      Caudal1-2 slices below the appearance of arytenoid cartilages, individually. Thus, the false vocal cords fall within the borders of the structureClinically, it varies from 0-1 cm below the free level of the true vocal cord, extending inferiorly from the lateral margin of the ventricle
      • Edge SB
      • Byrd DR
      • Compton CC
      • Fritz AG
      • Greene FL
      AJCC Cancer Staging Manual Seventh Edition.
      ,
      • Ferlito A
      • Rinaldo A.
      The pathology and management of subglottic cancer.
      ; from a practical point of view, the disappearance of the thyroid angle is a good landmark
      Anterior: mylohyoid muscle + anterior belly of the digastric muscle

      Posterior: root of the tongue and hyoid bone
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      Abbreviations: NA = not applicable.

      Oral cavity

      Opposite to the previously enumerated structures, the oral cavity is not an organ on its own, but an anatomic area within the mouth that is located anterior to the oropharynx.
      • Williams 3rd, DW
      An imager's guide to normal neck anatomy.
      Its contour includes the hard and soft palates, as well as the lingual tonsils, because their mucosa must be spared from an excessive dose of ionizing radiation. This consideration led us to an OAR contour that is somewhat larger than the oral cavity proper (ie, cavity behind dental arches, excluding oral vestibule between lips and teeth).
      • Dean JA
      • Welsh LC
      • Gulliford SL
      • Harrington KJ
      • Nutting CM.
      A novel method for delineation of oral mucosa for radiotherapy dose–response studies.

      Contouring suggestions

      Table 4 shows the recommended anatomic boundaries.
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.

      Pharyngeal constrictor muscles

      The muscles of the pharynx can be divided into an outer circular and inner longitudinal layer. The former includes the superior, middle, and inferior pharyngeal constrictor muscles, responsible for propelling the bolus into the esophagus.

      Contouring suggestions

      Apart from the pharyngeal constrictor muscles, various other structures play an indispensable role in the process of swallowing. These structures are the muscles of the floor of the mouth (anterior belly of digastric muscle, mylohyoid and geniohyoid muscle), thyrohyoid muscle, posterior digastric/stylohyoid muscle complex, longitudinal pair of the pharyngeal constrictors (ie, longitudinal pharyngeal muscles), hyoglossus/styloglossus complex, genioglossus muscle, and muscles responsible for tongue motion (intrinsic tongue muscles, referred to collectively as functional swallowing units [FSUs]).
      • Gawryszuk A
      • Bijl HP
      • Holwerda M
      • et al.
      Functional swallowing units (FSUs) as organs-at-risk for radiotherapy. PART 2: Advanced delineation guidelines for FSUs.
      ,
      • Gawryszuk A
      • Bijl HP
      • Holwerda M
      • et al.
      Functional swallowing units (FSUs) as organs-at-risk for radiotherapy. PART 1: Physiology and anatomy.
      The 3 major physiological roles of these structures are tongue motion, tongue base retraction, and hyolaryngeal elevation. The usefulness of FSU delineation in daily routine is a source of debate due to the extreme workload demand and eventual overlaps with other sensitive areas, such as the oral cavity and certain laryngeal structures. The contouring process might be facilitated in some cases by the usage of automatic OAR segmentation, as stated in the article by the MD Anderson Head and Neck Cancer Symptom Working Group.
      MD Anderson Head and Neck Cancer Symptom Working Group
      Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: Dose-volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy.
      To the best of our knowledge, neither dose constraints nor exact fields of implication have been defined for these structures.

      Contouring suggestions

      Table 5 shows the recommended anatomic boundaries.
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      • Popovtzer A
      • Cao Y
      • Feng FY
      • Eisbruch A.
      Anatomical changes in the pharyngeal constrictors after chemoirradiation of head and neck cancer and their dose-effect relationships: MRI-based study.
      Table 5Anatomic borders of pharyngeal constrictor muscles
      Organ boundariesSuperior pharyngeal constrictor muscleMiddle pharyngeal constrictor muscleInferior pharyngeal constrictor muscle
      AnteriorCaudal tip of the pterygoid plates
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      Hyoid bone, root of the tongue
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      Soft tissue of the larynx
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      PosteriorLongus capitis and colli muscles
      The former muscle stretches between the base of the skull (insertion: basilar part of occipital bone) and the upper cervical vertebrae (origin: transverse processes of third to sixth cervical vertebrae). The latter lies beneath the longus capitis muscle, on the anterior surface of vertebral bodies, and can be followed all the way down to the level of the upper thoracic vertebrae (origin: bodies of C5-Th3 vertebrae; insertion: anterior arch of the atlas).
      (ie, prevertebral muscles
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      ,
      • Dirix P
      • Abbeel S
      • Vanstraelen B
      • Hermans R
      • Nuyts S.
      Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: Dose–effect relationships for the swallowing structures.
      )
      MedialNot applicable (pharyngeal lumen)
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      LateralMedial pterygoid muscle,
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      parapharyngeal space
      Greater horn of hyoid bone
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      Superior horn of thyroid cartilage
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      ,
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      CranialCaudal tip of pterygoid plates
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      ,
      • Popovtzer A
      • Cao Y
      • Feng FY
      • Eisbruch A.
      Anatomical changes in the pharyngeal constrictors after chemoirradiation of head and neck cancer and their dose-effect relationships: MRI-based study.
      ,
      The pterygopharyngeal part of the superior pharyngeal constrictor muscle originates from the lower third of the medial pterygoid plate and its hamulus. Finding the pterygoid process on magnetic resonance images may be challenging; therefore, computed tomography correlation is advisable.
      Cranial edge of C3 vertebra
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      First slice caudal to the caudal edge of hyoid bone
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      CaudalCaudal edge of C2 vertebra
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      Caudal edge of hyoid bone
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      ,
      • Popovtzer A
      • Cao Y
      • Feng FY
      • Eisbruch A.
      Anatomical changes in the pharyngeal constrictors after chemoirradiation of head and neck cancer and their dose-effect relationships: MRI-based study.
      Caudal edge of arytenoid cartilages
      • Christianen MEMC
      • Langendijk JA
      • Westerlaan HE
      • van de Water TA
      • Bijl HP.
      Delineation of organs at risk involved in swallowing for radiotherapy treatment planning.
      low asterisk The former muscle stretches between the base of the skull (insertion: basilar part of occipital bone) and the upper cervical vertebrae (origin: transverse processes of third to sixth cervical vertebrae). The latter lies beneath the longus capitis muscle, on the anterior surface of vertebral bodies, and can be followed all the way down to the level of the upper thoracic vertebrae (origin: bodies of C5-Th3 vertebrae; insertion: anterior arch of the atlas).
      The pterygopharyngeal part of the superior pharyngeal constrictor muscle originates from the lower third of the medial pterygoid plate and its hamulus. Finding the pterygoid process on magnetic resonance images may be challenging; therefore, computed tomography correlation is advisable.

      Inner ear

      The inner ear is composed of 2 main functional parts (cochlea and vestibular system), which consist of an outer bony labyrinth, a network of passages with bony walls within the petrous part of the temporal bone, and an inner fluid-filled membranous labyrinth. The cochlea is a spiraled tunnel that makes 2.75 turns about its axis, the modiolus (perpendicular to longitudinal axis of petrous bone). The semicircular canals are situated posterolaterally to the cochlea, and made up of 3 tubes according to the 3 main planes of space, interconnected by a central vestibule.
      • Bhandare N
      • Jackson A
      • Eisbruch A
      • et al.
      Radiation therapy and hearing loss.

      Contouring suggestions

      The cochlea and vestibular system have been delineated separately in some cases. However, due to the proximity of the 2 structures, we defined the inner ear as 1 single OAR, per the practice of Sun et al.
      • Sun Y
      • Yu XL
      • Luo W
      • et al.
      Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy.

      Eye (eyeball)

      The eyeball consists of 3 outer tunics (sclera, choroid, and retina), encompassing the core of the eye itself, which can be subdivided into 4 further anatomic structures (anterior and posterior chambers, lens, and vitreous body). However, finer microscopic anatomic details cannot be observed on MRI scans.

      Contouring suggestions

      A meticulous delineation of the fluid filling the anterior chamber and vitreous body can be carried out. The extension of this contour by 1 mm (corresponding to outer layers of the eye) in all dimensions may also lead to an adequate OAR contour.

      Lens

      The lens of the eye is a biconvex, lentiform structure suspended between the iris and vitreous body. Its overall diameter typically ranges between 9 and 10 mm, with a thickness of approximately 4.5 mm, although this varies with age.

      Optic nerve

      Also known as cranial nerve II, the optic nerve is composed of ganglion cell axons that carry the excitation of retinal photoreceptors to the vision centers of the cortex. The orbital portion of the nerve is usually between 20 and 30 mm in length and 2 to 5 mm in thickness. The optic nerve travels in the axis of the orbit, above the rectus inferior muscle, and below the rectus superior, and enters the cranial cavity via the optic canal to end in the optic chiasm. The intracranial segment of the optic nerve is approximately 10 mm long.

      Contouring suggestions

      The optic nerve can be confused with the rectus superior and inferior muscles. The muscles have a flat, shorter appearance, and the nerve is slimmer and longer. The meningeal layers unsheathing the nerve have also been included in the contour.

      Optic chiasm

      The optic chiasm is the location of the partial decussation of optic fibers, and rests on the tuberculum sellae in the suprasellar cistern. The crossing fibers form an x-shape, posteriorly bordered by the pituitary stalk, laterally by the internal carotid arteries, and inferiorly by the third ventricle. The circle of Willis encircles the pituitary stalk and optic chiasm. The overall size of the structure is usually 14 × 8 × 5 mm.
      • Eekers DBP
      • in ’t Ven L
      • Roelofs E
      • et al.
      The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology.

      Contouring suggestions

      The x-shape is not always visible on 1 single section, especially when operating with small slice thickness (≤1 mm). In such cases, the fibers of the optic nerve entering the chiasma and the axons forming the optic tract can be delineated on consecutive MRI slices. The pituitary stalk and internal carotid arteries may be delineated additionally to help distinguish between the chiasm and the surrounding structures.

      Lacrimal gland

      The lacrimal gland is a small exocrine gland situated in a shallow depression of the superolateral corner of the orbit.

      Contouring suggestions

      The easiest way to find the lacrimal gland is to look for an approximate 15- × 20- × 5-mm area with low signal intensity above the lateral rectus muscle and laterally to the superior rectus muscle.
      • Scoccianti S
      • Detti B
      • Gadda D
      • et al.
      Organs at risk in the brain and their dose-constraints in adults and in children: A radiation oncologist's guide for delineation in everyday practice.
      The volume of the lacrimal gland is usually around 0.6 cm3 with slight right-sided dominance.
      • Bulbul E
      • Yazici A
      • Yanik B
      • Yazici H
      • Demirpolat G.
      Evaluation of lacrimal gland dimensions and volume in Turkish population with computed tomography.
      ,
      • Totuk OMG
      • Kalkay AB
      • Kabadayi K
      • Demir MK
      • Barut C.
      Evaluation of lacrimal gland dimensions with MR imaging in a Turkish population sample.

      Brain stem

      The rostral continuation of the spinal cord can be divided into 3 levels in rostrocaudal order. The lowermost one-third, the medulla oblongata, has no well-determined inferior border, because transition from the spinal cord to the brain stem is continuous. To overcome this uncertainty, we commenced the contouring of the medulla at the level where the tip of the odontoid process first appears in concordance with CT-based guidelines.
      • Brouwer CL
      • Steenbakkers RJHM
      • Bourhis J
      • et al.
      CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
      The rostral limit of the mesencephalon, or midbrain (uppermost third of brain stem) is similarly ill-defined. A recent study on OAR contouring in the central nervous system using MRI technique suggested the delineation of the midbrain until the nigral substance disappeared.
      • Eekers DBP
      • in ’t Ven L
      • Roelofs E
      • et al.
      The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology.
      The previously mentioned CT-based consensus guideline defines the cranial beginning of the midbrain as the bottom section of the lateral ventricles. We do not entirely agree with this approach, because the temporal horns of the lateral ventricles appear already at the level of the pontomesencephalic junction and therefore, more caudally than the expected organ margin. We found that the central part of the lateral ventricle is a more reliable landmark for the upper border of the mesencephalon. Another study by Beddok et al
      • Beddok A
      • Faivre JC
      • Coutte A
      • et al.
      Practical contouring guidelines with an MR-based atlas of brainstem structures involved in radiation-induced nausea and vomiting.
      • Adachi M
      • Hosoya T
      • Haku T
      • Yamaguchi K
      • Kawanami T.
      Evaluation of the substantia nigra in patients with Parkinsonian syndrome accomplished using multishot diffusion-weighted MR imaging.
      suggested placing the brain stem between the upper- and lowermost endpoints of the Sylvian aqueduct, a cerebrospinal fluid–filled narrow cavity that is well visible in the sagittal plane.

      Contouring suggestions

      The average volume of the brain stem is expected to fall between 27 and 43 cm3.
      • Mayo C
      • Yorke E
      • Merchant TE.
      Radiation associated brainstem injury.

      Spinal cord

      The spinal cord is the caudal continuation of the brain stem, extending from the lowermost section of the medulla to the intervertebral disc between the first and second lumbar vertebrae.
      • Wada M
      • Premoselli L
      • Rolfo A
      • et al.
      Determination of accuracy in the delineation of spinal cord and canal/thecal sac on CT and MRI in head and neck planning.

      Brain

      The brain contour includes the brain stem, diencephalon, cerebellum, hemispheria of the telencephalon, smaller cerebral vessels, and cerebrospinal fluid. Our approach treats the brain stem as a subunit of the OAR brain; therefore, the lowermost section of these 2 is located in an identical plane.

      Contouring suggestions

      The contouring of this organ mainly involves following the outline of the cerebrospinal fluid in the subarachnoid space.

      Pituitary gland

      The pituitary gland, or hypophysis, is a cherry-sized endocrine organ located within the cranial cavity. This gland can be regarded as a caudal protrusion of the hypothalamus, connected by the pituitary stalk to the latter.
      • Combs SE
      • Baumert BG
      • Bendszus M
      • et al.
      ESTRO ACROP guideline for target volume delineation of skull base tumors.

      Contouring suggestions

      The hypophysis rests in a small, saddle-shaped, bony nest of the sphenoid bone, the sella turcica. The organ itself is usually well visible on any diagnostic T2-weighted MRI sequences, although the sella itself is difficult to find. On CT scans with an appropriate bone window, the clinoid processes, dorsum and tuberculum sellae, important anatomic landmarks bordering the hypophyseal fossa, and thus, hypophysis, can be localized.

      Thyroid gland

      The thyroid gland is an endocrine organ that lies against and around the thyroid and cricoid cartilages of the larynx. This gland is made up of 2 elongated lobes interconnected by a narrow isthmus, giving the thyroids the shape of a butterfly. The size of the lobes may vary on a wide range, but the average anteroposterior diameter of the organ usually falls between 13 and 28 mms, with a length of 40 to 60 mm. The volume of the OAR is 12 to 18 mL in the male and 10 to 15 mL in the female population.
      • Chaudhary V
      • Bano S
      Thyroid ultrasound.
      ,
      • Kang T
      • Kim DW
      • Lee YJ
      • et al.
      Magnetic resonance imaging features of normal thyroid parenchyma and incidental diffuse thyroid disease: A single-center study.

      Brachial plexus

      The brachial plexus is a network of nerves that provides sensory and motor innervation of the upper limb and shoulder girth. The course of the plexus can be divided into 4 distinct portions, each related to characteristic anatomic landmarks. The first portion (ie, radices or roots of brachial plexus correspond to anterior rami of C5-T1 spinal nerves). These roots later merge to form the superior, middle, and inferior trunks of the plexus, which are situated above the clavicle, in the scalene hiatus. Behind the clavicle, each trunk splits in 2, forming a total of 6 divisions. The last portion of the brachial plexus are cords, located below the clavicle, in the axillary fossa, and are named by their position with respect to the axillary artery.

      Contouring suggestions

      The recommended anatomic boundaries
      • Truong MT
      • Nadgir RN
      • Hirsch AE
      • et al.
      Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.
      • Hall WH
      • Guiou M
      • Lee NY
      • et al.
      Development and validation of a standardized method for contouring the brachial plexus: Preliminary dosimetric analysis among patients treated with IMRT for head-and-neck cancer.
      • Yi SK
      • Hall WH
      • Mathai M
      • et al.
      Validating the RTOG-endorsed brachial plexus contouring atlas: An evaluation of re-producibility among patients treated by intensity modulated radiotherapy for head-and-neck cancer.
      • Van de Velde J
      • Audenaert E
      • Speleers B
      • et al.
      An anatomically validated brachial plexus contouring method for intensity modulated radiation therapy planning.
      for the brachial plexus are included in Table 6.
      Table 6Anatomic borders of brachial plexus
      RootsTrunksDivisionsCords
      First, the intervertebral foramina between C4-C5 and T1-T2 should be identified.
      • Truong MT
      • Nadgir RN
      • Hirsch AE
      • et al.
      Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.
      ,
      • Hall WH
      • Guiou M
      • Lee NY
      • et al.
      Development and validation of a standardized method for contouring the brachial plexus: Preliminary dosimetric analysis among patients treated with IMRT for head-and-neck cancer.
      Of note, cervical spinal nerves emerge above their corresponding vertebrae,
      Unlike the rest of the spinal nerves that leave the spinal canal below their corresponding vertebrae.
      which is why the fifth cervical spinal nerve is found above the fourth cervical vertebra.
      The next step is delineating the trunks of the brachial plexus in the scalene hiatus.
      • Truong MT
      • Nadgir RN
      • Hirsch AE
      • et al.
      Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.
      ,
      • Hall WH
      • Guiou M
      • Lee NY
      • et al.
      Development and validation of a standardized method for contouring the brachial plexus: Preliminary dosimetric analysis among patients treated with IMRT for head-and-neck cancer.
      The anterior and middle scalene muscles may also be contoured to better understand anatomic relations.
      The last 2 portions of the brachial plexus are defined as the posterior part of the subclavian and axillary neurovascular bundle, below the insertion of the middle scalene muscle and the sternal extremity of the clavicle.
      • Truong MT
      • Nadgir RN
      • Hirsch AE
      • et al.
      Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.
      ,
      • Yi SK
      • Hall WH
      • Mathai M
      • et al.
      Validating the RTOG-endorsed brachial plexus contouring atlas: An evaluation of re-producibility among patients treated by intensity modulated radiotherapy for head-and-neck cancer.
      A 5-mm paint tool thickness is recommended for the delineation of the organ at risk.
      • Hall WH
      • Guiou M
      • Lee NY
      • et al.
      Development and validation of a standardized method for contouring the brachial plexus: Preliminary dosimetric analysis among patients treated with IMRT for head-and-neck cancer.
      ,
      • Yi SK
      • Hall WH
      • Mathai M
      • et al.
      Validating the RTOG-endorsed brachial plexus contouring atlas: An evaluation of re-producibility among patients treated by intensity modulated radiotherapy for head-and-neck cancer.
      Furthermore, Van der Velde et al suggested adding a margin of 4.7 mm around this brachial plexus contour to achieve full coverage of organ-at-risk and anatomic variants.
      • Van de Velde J
      • Audenaert E
      • Speleers B
      • et al.
      An anatomically validated brachial plexus contouring method for intensity modulated radiation therapy planning.
      low asterisk Unlike the rest of the spinal nerves that leave the spinal canal below their corresponding vertebrae.
      Table 2Comparison between T1- and T2-weighted MRI sequences and CT
      OrganT1wT2wCTRemarks
      Parotid glands232Any diagnostic T2w MRI sequence is eligible for delineation purposes because the saliva content of the glands creates a well-visible contrast with the surrounding tissues
      Submandibular glands232Similar MRI morphology to the parotid glands
      Mandible223Contouring the mandible on CT is easier owing to the sharp contrast between the hyperdense bone and the surrounding soft tissues. On T2w MRI, the cortical bone appears as a low signal intensity layer enveloping the inhomogeneous spongious bone
      Supraglottic larynx222
      Glottic larynx/glottic area222Nonossified cartilages appear with intermediate signal intensity on T2w images. Ossified cartilages are similar to bone (ie, high signal central marrow and low signal cortical rim)
      • Castelijns JA
      • Doornbos J
      • Verbeeten Jr, B
      • Vielvoye GJ
      • Bloem JL.
      MR imaging of the normal larynx.
      Oral cavity221The visibility of the muscles of the floor of the mouth and palate is poor on CT; therefore, the cranial and caudal borders of the region is hard to define. The usage of coronal and sagittal MRI slices beside the axial plane is crucial to correctly define the craniocaudal and laterolateral extent of the oral cavity
      • Dean JA
      • Welsh LC
      • Gulliford SL
      • Harrington KJ
      • Nutting CM.
      A novel method for delineation of oral mucosa for radiotherapy dose–response studies.
      Pharyngeal constrictor muscles231The constrictor muscles are virtually not distinguishable on CT
      Inner ear122The fluid content of both the cochlea and semicircular canals is discernible on T2w MRI images; it is surrounded by a narrow, hypointense zone, corresponding to the compact substance of the bony labyrinth
      Eye (eyeball)232Greater contrast on T2 between the tunics of the eyeball (ie, outer border of organ; hypointense), fluid (hyperintense), and tissues of the orbit
      Lens333Well visible on T1 and T2
      Optic nerve332
      Optic chiasm331
      Lacrimal gland121Similar MRI morphology to the parotid and submandibular glands
      Brain stem331The demarcation of the organ from the liquor is clearly visible on T2w MRI. On these scans, the nigral substance appears as a longitudinal stripe of higher signal intensity compared with the neighboring red nucleus and pes pedunculi.
      • Adachi M
      • Hosoya T
      • Haku T
      • Yamaguchi K
      • Kawanami T.
      Evaluation of the substantia nigra in patients with Parkinsonian syndrome accomplished using multishot diffusion-weighted MR imaging.
      Spinal cord231Only the spinal cord proper is included in the contour, not the entire spinal canal. Contouring the spinal canal was performed mainly owing to the poor image quality and low contrast on native topometric CT scans.
      • Wada M
      • Premoselli L
      • Rolfo A
      • et al.
      Determination of accuracy in the delineation of spinal cord and canal/thecal sac on CT and MRI in head and neck planning.
      Brain332
      Pituitary gland222Thin MRI slices (thickness: 1 mm) with CT correlation is recommended for delineation purposes
      • Combs SE
      • Baumert BG
      • Bendszus M
      • et al.
      ESTRO ACROP guideline for target volume delineation of skull base tumors.
      Thyroid gland222Similar MRI morphology to the parotid and submandibular glands
      Brachial plexus221
      Esophagus222Hyperintense to muscle on T2w images
      • Combs SE
      • Baumert BG
      • Bendszus M
      • et al.
      ESTRO ACROP guideline for target volume delineation of skull base tumors.
      Sum435035
      Abbreviations: CT = computed tomography; MRI = magnetic resonance imaging.
      Visibility of organs is graded from 1 to 3, with 3 = excellent, 2 = average, and 1 = poor visibility.

      Esophagus

      Starting at the level of the sixth cervical vertebra, the thumb-thick food pipe interconnects the pharynx with the cardia of the stomach, and rests on the vertebral bodies, just behind the larynx and trachea.
      • Combs SE
      • Baumert BG
      • Bendszus M
      • et al.
      ESTRO ACROP guideline for target volume delineation of skull base tumors.

      Contouring suggestions

      Between the ventral trachea and dorsal esophagus runs the shallow tracheoesophageal groove, which contains the recurrent laryngeal nerve. The sparing of this nerve may be desirable to prevent late-onset radiation-induced neuropathy.
      • Shultz DB
      • Trakul N
      • Maxim PG
      • Diehn M
      • Loo Jr., BW
      Vagal and recurrent laryngeal neuropathy following stereotactic radiation therapy in the chest.
      ,
      • Jaruchinda P
      • Jindavijak S
      • Singhavarach N.
      Radiation-related vocal fold palsy in patients with head and neck carcinoma.

      Discussion

      The role of novel anatomic structures and subsites as potential OARs emerges, just as we have seen in the case of masticatory muscles
      • Zhang X
      • Chen H
      • Chen W
      • et al.
      Technical note: Atlas-based auto-segmentation of masticatory muscles for head and neck cancer radiotherapy.
      or the freshly described tubarial salivary glands.
      • Valstar MH
      • de Bakker BS
      • Steenbakkers RJHM
      • et al.
      The tubarial salivary glands: A potential new organ at risk for radiotherapy.
      With the growing number of clinical trials requiring MRI-based RT planning, the need for well-built, straightforward contouring guidelines
      • Grégoire V
      • Evans M
      • Le QT
      • et al.
      Delineation of the primary tumour clinical target volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
      ,
      • Lin D
      • Lapen K
      • Sherer MV
      • et al.
      A systematic review of contouring guidelines in radiation oncology: Analysis of frequency, methodology, and delivery of consensus recommendations.
      is on the rise. Automated OAR segmentation (not only in the H&N region), combined with MRI-based imaging, may lead to increased accuracy in terms of organ boundaries and decreased interobserver variability.
      • Ayyalusamy A
      • Vellaiyan S
      • Subramanian S
      • et al.
      Auto-segmentation of head and neck organs at risk in radiotherapy and its dependence on anatomic similarity.
      ,
      • Tong N
      • Gou S
      • Yang S
      • Ruan D
      • Sheng K.
      Fully automatic multi-organ segmentation for head and neck cancer radiotherapy using shape representation model constrained fully convolutional neural networks.
      Generally speaking, the rapid evolution of artificial intelligence–based contouring software may take a huge burden off the shoulders of radiographers and radiation oncologists, and may result in the expansion of this proposed organ set. OAR delineation should always be governed by clinical rationality that takes into account disease stage, tumor volume, and involvement/infiltration of different anatomic structures, functional units, as well as the curative or palliative intent of the radiation therapy itself.

      Conclusion

      Within the framework of cooperation between several European clinical centers, a consensus guideline was established on OAR delineation in the H&N region, using exclusively magnetic resonance images. Such uniform guidelines may increase treatment accuracy and facilitate the comparison of results between different centers, collaborations, and multi-institutional clinical trials.

      Appendix. Supplementary materials

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